The Bills hold a 9-8 overall record in the rivalry and are 5-3 in Buffalo. The Jaguars have won the last two meetings (neither in Buffalo) and, counting a 10-3 playoff victory on Jan. 7, 2018, have won four of the last six meetings. The Jags are 2-0 vs. Buffalo in playoff games.

Buffalo lost former All-Pro linebacker Matt Milano to a torn biceps in training camp. All-Pro nickel back Taron Johnson went down with a forearm injury on the seventh play of the season. Linebacker Terrel Bernard, the Bills' leading tackler a year ago, exited with a pectoral strain in the first quarter in Week 2.